If you are craving a bold, comforting dinner, this Spicy Southern Cheesy Chicken Spaghetti Casserole delivers big flavor in every bite. Creamy, cheesy, slightly spicy, and deeply satisfying, this Southern classic is the kind of baked pasta dish that brings everyone to the table fast.
This recipe blends tender shredded chicken, perfectly cooked spaghetti, rich cheese, and a touch of heat into one bubbling casserole that feels both nostalgic and exciting. It is ideal for busy weeknights, family gatherings, church suppers, or anytime you want a guaranteed crowd-pleaser.
Why You’ll Love This Spicy Southern Cheesy Chicken Spaghetti Casserole
This casserole has everything you want in a comfort food meal, plus a little Southern flair.
First, it is incredibly easy to make. Most of the ingredients are pantry staples, and you can even use rotisserie chicken to save time. Everything comes together in one big baking dish, which means fewer dishes and less cleanup.
Second, the flavor balance is spot on. The creamy cheese sauce softens the heat from the tomatoes with green chilies, while spices add warmth without overpowering the dish. It is spicy enough to be exciting but mild enough for most families.
Finally, this recipe is perfect for leftovers. It reheats beautifully, freezes well, and tastes even better the next day as the flavors meld together.
Ingredients for Spicy Southern Cheesy Chicken Spaghetti Casserole
Main Casserole Ingredients
- 12 oz dry spaghetti
- 2 cups cooked chicken, shredded or diced
- 2 tablespoons olive oil or butter
- 1 medium onion, finely diced
- 2 stalks celery, finely chopped
- 2 cloves garlic, minced
- 1 can (10 oz) diced tomatoes with green chilies, drained
- 1 can (10.5 oz) cream of chicken soup
- 1 cup chicken broth
- 2 cups sharp cheddar cheese, shredded
- 1 cup pepper jack cheese, shredded
Seasonings and Spice
- 1 teaspoon garlic powder
- 1 teaspoon onion powder
- 1 teaspoon smoked paprika
- 1 half teaspoon cayenne pepper, adjust to taste
- Salt and black pepper to taste
Optional Topping
- 1 half cup extra shredded cheddar or pepper jack cheese
- Chopped green onions or parsley for garnish
Ingredient Notes and Substitutions
If you prefer a milder casserole, you can use diced tomatoes without chilies and skip the cayenne pepper. The dish will still be flavorful and comforting.
For a lighter version, replace one cup of cheese with reduced-fat cheese and use low-sodium soup and broth. You can also add more vegetables like bell peppers or mushrooms to stretch the recipe.
If you do not have cream of chicken soup, cream of mushroom works just as well. Both create that classic creamy Southern casserole texture.
This recipe contains no alcohol or pork. If you want a smoky flavor without bacon, smoked paprika or a small amount of liquid smoke works beautifully.
Step-by-Step Instructions
Step 1: Cook the Spaghetti
Bring a large pot of salted water to a boil. Cook the spaghetti according to package directions until just al dente. Drain well and set aside. Do not overcook, as the pasta will continue to soften while baking.
Step 2: Sauté the Vegetables
In a large skillet over medium heat, add the olive oil or butter. Sauté the diced onion and celery for about 4 to 5 minutes, until softened. Add the minced garlic and cook for 30 seconds, just until fragrant.
Step 3: Build the Sauce
Lower the heat slightly. Stir in the cream of chicken soup, chicken broth, garlic powder, onion powder, smoked paprika, cayenne pepper, salt, and black pepper. Mix until smooth and creamy.
Add the drained tomatoes with green chilies and stir well. Let the sauce simmer gently for 2 to 3 minutes so the flavors can blend.
Step 4: Add Chicken and Cheese
Stir in the cooked chicken, followed by the shredded cheddar and pepper jack cheese. Continue stirring until the cheese is melted and the sauce is thick and creamy.
Step 5: Combine with Spaghetti
Add the cooked spaghetti directly into the skillet. Gently toss until every strand is coated in the cheesy sauce.
Step 6: Assemble the Casserole
Preheat your oven to 350°F. Lightly grease a 9×13 inch baking dish. Transfer the spaghetti mixture into the dish and spread it evenly. Sprinkle extra cheese on top if desired.
Step 7: Bake Until Bubbly
Bake uncovered for 25 to 30 minutes, until the casserole is hot, bubbly, and lightly golden on top. Let it rest for 5 to 10 minutes before serving so it sets up nicely.
Pro Tips for Success
- Always cook the spaghetti just to al dente to avoid a mushy casserole.
- Shred your own cheese if possible. It melts better and creates a smoother sauce.
- Taste the sauce before baking and adjust seasoning or spice level as needed.
- Let the casserole rest after baking for cleaner slices and better texture.
- For extra heat lovers, add sliced jalapeños or a pinch of crushed red pepper flakes.
Flavor Variations
This Spicy Southern Cheesy Chicken Spaghetti Casserole is incredibly flexible. Here are a few delicious ways to change it up.
- Extra Southern Style: Add diced bell peppers and a dash of Cajun seasoning.
- Buffalo Chicken Twist: Stir in 2 tablespoons of mild buffalo sauce and use Monterey Jack cheese.
- Veggie Loaded: Add sautéed mushrooms, zucchini, or spinach for extra nutrition.
- Ultra Creamy: Stir in 4 oz of cream cheese with the soup mixture.
- Kid Friendly: Use mild cheddar and skip the cayenne and chilies.
Serving Suggestions
This casserole is hearty enough to stand on its own, but pairing it with simple sides makes it even better.
Serve it with a crisp green salad and a tangy vinaigrette to balance the richness. Garlic bread or warm dinner rolls are perfect for soaking up extra sauce. For a true Southern spread, add green beans, coleslaw, or roasted corn on the side.
Storage and Freezing Instructions
Store leftovers in an airtight container in the refrigerator for up to 4 days. Reheat individual portions in the microwave or warm larger portions in the oven at 325°F until heated through.
To freeze, let the casserole cool completely. Wrap tightly in plastic wrap and foil, or transfer to a freezer-safe container. Freeze for up to 3 months. Thaw overnight in the refrigerator before reheating.
Nutrition Facts (Per Serving)
| Nutrient | Amount |
|---|---|
| Calories | ~520 |
| Protein | 32 g |
| Carbohydrates | 38 g |
| Fat | 26 g |
| Fiber | 3 g |
| Sodium | ~780 mg |
Values are approximate and will vary based on ingredients used.
FAQ About Spicy Southern Cheesy Chicken Spaghetti Casserole
Can I make this casserole ahead of time?
Yes, this casserole is perfect for meal prep. Assemble everything up to the baking step, cover tightly, and refrigerate for up to 24 hours. Bake when ready, adding a few extra minutes to the cooking time.
Is this casserole very spicy?
It has a gentle heat that most people find enjoyable. You can easily control the spice by reducing or increasing the cayenne and choosing mild or hot tomatoes with chilies.
What is the best chicken to use?
Rotisserie chicken is the easiest option and adds great flavor. You can also use baked, poached, or leftover grilled chicken.
Can I use a different pasta shape?
Yes, while spaghetti is traditional, penne, rotini, or fettuccine work well. Just cook the pasta al dente so it holds up during baking.
How do I keep the casserole from drying out?
Make sure there is enough sauce before baking and do not overbake. Cover loosely with foil if the top browns too quickly.
Spicy Southern Cheesy Chicken Spaghetti Casserole
Equipment
- large pot for cooking spaghetti
- large skillet for sauce and mixing
- wooden spoon or spatula
- 9×13-inch baking dish
- oven
Ingredients
- 12 oz dry spaghetti
- 2 cups cooked chicken, shredded or diced
- 2 tbsp olive oil or butter
- 1 medium onion, finely diced
- 2 stalks celery, finely chopped
- 2 cloves garlic, minced
- 10 oz diced tomatoes with green chilies, drained
- 10.5 oz cream of chicken soup
- 1 cup chicken broth
- 2 cups sharp cheddar cheese, shredded
- 1 cup pepper jack cheese, shredded
- 1 tsp garlic powder
- 1 tsp onion powder
- 1 tsp smoked paprika
- 0.5 tsp cayenne pepper
- salt, to taste
- black pepper, to taste
- 0.5 cup extra shredded cheese for topping (optional)
Instructions
- Bring a large pot of salted water to a boil. Cook the spaghetti until just al dente according to package directions. Drain well and set aside.
- Heat olive oil or butter in a large skillet over medium heat. Sauté onion and celery for 4–5 minutes until softened. Add garlic and cook 30 seconds until fragrant.
- Reduce heat and stir in cream of chicken soup, chicken broth, garlic powder, onion powder, smoked paprika, cayenne, salt, and pepper until smooth.
- Add drained tomatoes with green chilies and simmer gently for 2–3 minutes to blend flavors.
- Mix in cooked chicken, cheddar cheese, and pepper jack cheese. Stir until melted and creamy.
- Add cooked spaghetti to the skillet and gently toss until fully coated with sauce.
- Preheat oven to 350°F. Transfer mixture to a greased 9×13-inch baking dish, top with extra cheese if desired, and bake uncovered for 25–30 minutes until bubbly and lightly golden.
Notes
Nutrition
Final Thoughts
This Spicy Southern Cheesy Chicken Spaghetti Casserole is the kind of recipe that earns a permanent place in your dinner rotation. It is comforting, customizable, and packed with bold Southern flavor that feels like home. Whether you are feeding a hungry family or preparing a dish to share, this casserole always delivers smiles and empty plates.
Once you try it, you will understand why this classic continues to be loved across generations.
